Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

Recent advances in our understanding of tissue regeneration and the development of
efficient approaches to induce and differentiate pluripotent stem cells for cell replacement …

The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue
engineering strategies focusing on biomaterial scaffolds incorporating cells and growth …

Transduction of mechanical forces and chemical signals affect every cell in the human body.
Fluid flow in systems such as the lymphatic or circulatory systems modulates not only cell …

Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

Considering the feasibility of remote on–off control and deep tissue penetration, magnetic-
manipulation is highly desirable to provide on-demand extracellular matrix (ECM) signaling …

Substrate stiffness has been indicated as a primary determinant for stem cell fate, being
capable of influencing motility, proliferation, and differentiation. Although the effects of …

Human pluripotent stem cells (hPSC) have attracted a great attention as an unlimited source
of cells for cell therapies and other in vitro biomedical applications such as drug screening …

Background Skin is a soft tissue that forms roughly 8% of the total body mass and covers the
entire surface area of the body. It is a self-repairing, self-renewing organ that forms an …