[HTML][HTML] Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
[HTML][HTML] The biological activities of butyrylcholinesterase inhibitors
S Zhou, G Huang - Biomedicine & pharmacotherapy, 2022 - Elsevier
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
Efficient synthesis, antibacterial, antifungal, antioxidant and cytotoxicity study of 2‐(2‐hydrazineyl) thiazole derivatives
VA Adole, RA More, BS Jagdale, TB Pawar… - …, 2020 - Wiley Online Library
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …
Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
A series of thirty (30) thiazole analogs were prepared, characterized by 1 H NMR, 13 C NMR
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
Benzylpiperidine-linked diarylthiazoles as potential anti-Alzheimer's agents: synthesis and biological evaluation
M Shidore, J Machhi, K Shingala… - Journal of medicinal …, 2016 - ACS Publications
A novel series of hybrid molecules were designed and synthesized by fusing the
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …
Synthesis and evaluation of novel xanthene‐based thiazoles as potential antidiabetic agents
A series of xanthene‐based thiazoles was synthesized and characterized by different
scpectroscopic methods, ie Proton nuclear magnetic resonance (1H NMR), carbon nuclear …
scpectroscopic methods, ie Proton nuclear magnetic resonance (1H NMR), carbon nuclear …
Pharmacological report of recently designed multifunctional coumarin and coumarin–heterocycle derivatives
A Dorababu - Archiv der Pharmazie, 2022 - Wiley Online Library
Coumarin is a naturally available molecule and has been identified as a potent
pharmacophore due to its pharmacological activity. Because of this, coumarin has been …
pharmacophore due to its pharmacological activity. Because of this, coumarin has been …
[HTML][HTML] Design, synthesis, in vitro biological assessment and in silico molecular modeling study of thiazole-thiazolidinone derivatives as potent anti-cancer agents
The current study addressed the synthesis of thiazole-based thiazolidinone derivatives (1–
18) using stepwise reaction processes, and their structure was confirmed using various …
18) using stepwise reaction processes, and their structure was confirmed using various …
Synthesis, computational and antimicrobial study of 2-(2-Hydrazinyl) thiazole derivatives
RA Shinde, VA Adole, BS Jagdale - Journal of Molecular Structure, 2024 - Elsevier
In the present investigation, we report a combined computational and experimental study of
eight thiazole derivatives (4a-4h) obtained from 3, 4-dihydronaphthalen-1 (2H)-one. A green …
eight thiazole derivatives (4a-4h) obtained from 3, 4-dihydronaphthalen-1 (2H)-one. A green …