[HTML][HTML] Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

[HTML][HTML] The biological activities of butyrylcholinesterase inhibitors

S Zhou, G Huang - Biomedicine & pharmacotherapy, 2022 - Elsevier
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …

Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds

B Sever, C Türkeş, MD Altıntop, Y Demir… - Archiv der …, 2021 - Wiley Online Library
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …

Efficient synthesis, antibacterial, antifungal, antioxidant and cytotoxicity study of 2‐(2‐hydrazineyl) thiazole derivatives

VA Adole, RA More, BS Jagdale, TB Pawar… - …, 2020 - Wiley Online Library
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease

F Rahim, MT Javed, H Ullah, A Wadood, M Taha… - Bioorganic …, 2015 - Elsevier
A series of thirty (30) thiazole analogs were prepared, characterized by 1 H NMR, 13 C NMR
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …

Benzylpiperidine-linked diarylthiazoles as potential anti-Alzheimer's agents: synthesis and biological evaluation

M Shidore, J Machhi, K Shingala… - Journal of medicinal …, 2016 - ACS Publications
A novel series of hybrid molecules were designed and synthesized by fusing the
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …

Synthesis and evaluation of novel xanthene‐based thiazoles as potential antidiabetic agents

S Naseem, Z Shafiq, P Taslimi, S Hussain… - Archiv der …, 2023 - Wiley Online Library
A series of xanthene‐based thiazoles was synthesized and characterized by different
scpectroscopic methods, ie Proton nuclear magnetic resonance (1H NMR), carbon nuclear …

Pharmacological report of recently designed multifunctional coumarin and coumarin–heterocycle derivatives

A Dorababu - Archiv der Pharmazie, 2022 - Wiley Online Library
Coumarin is a naturally available molecule and has been identified as a potent
pharmacophore due to its pharmacological activity. Because of this, coumarin has been …

[HTML][HTML] Design, synthesis, in vitro biological assessment and in silico molecular modeling study of thiazole-thiazolidinone derivatives as potent anti-cancer agents

S Khan, H Ullah, R Hussain, MU Khan, Y Khan… - Results in …, 2024 - Elsevier
The current study addressed the synthesis of thiazole-based thiazolidinone derivatives (1–
18) using stepwise reaction processes, and their structure was confirmed using various …

Synthesis, computational and antimicrobial study of 2-(2-Hydrazinyl) thiazole derivatives

RA Shinde, VA Adole, BS Jagdale - Journal of Molecular Structure, 2024 - Elsevier
In the present investigation, we report a combined computational and experimental study of
eight thiazole derivatives (4a-4h) obtained from 3, 4-dihydronaphthalen-1 (2H)-one. A green …