Many of our present medicines are derived directly or indirectly from higher plants. While
several classic plant drugs have lost much ground to synthetic competitors, others have …

ContextRecent studies have found that when investigators have financial relationships with
pharmaceutical or product manufacturers, they are less likely to criticize the safety or efficacy …

Some anti-cancer treatments (eg, immunotherapies) determine, on the long term, a durable
survival in a small percentage of treated patients; in graphical terms, long-term survivors …

The antitumour agent paclitaxel has proved to be effective for the treatment of patients with
metastatic breast or ovarian cancer, and limited data also indicate its clinical potential in …

Objective: Lamotrigine as add-on treatment (500 mg per day) is effective in patients with
refractory epilepsy, but its high cost requires a pharmacoeconomic analysis. We conducted …

Background Adjuvant chemotherapy is a key component of advanced ovarian cancer
treatment, when surgery alone is not sufficient. Recurrence is common in ovarian cancer …

Concomitant radiochemotherapy followed by six cycles of temozolomide (= short term) is
considered as standard therapy for adults with newly diagnosed glioblastoma. In contrast …

Objective: In patients with amyotrophic lateral sclerosis, long term treatment with riluzole has
been reported to improve survival or tracheostomy-free survival in comparison with placebo …

Objectives To assess the methodological quality of Italian health economic evaluations and
their generalizability or transferability to different settings. Methods A literature search was …

Paclitaxel is a new cytotoxic agent that has demonstrated significant activity in advanced
ovarian cancer. The aim of this study was to determine the cost structure of advanced …