Bacterial contamination of platelets for transfusion: strategies for prevention

JH Levy, MD Neal, JH Herman - Critical Care, 2018 - Springer
Platelet transfusions carry greater risks of infection, sepsis, and death than any other blood
product, owing primarily to bacterial contamination. Many patients may be at particular risk …

Pathogen reduction technology treatment of platelets, plasma and whole blood using riboflavin and UV light

S Marschner, R Goodrich - Transfusion medicine and Hemotherapy, 2011 - karger.com
Bacterial contamination and emerging infections combined with increased international
travel pose a great risk to the safety of the blood supply. Tests to detect the presence of …

Infectious keratitis treated with corneal crosslinking

K Makdoumi, J Mortensen, S Crafoord - Cornea, 2010 - journals.lww.com
Purpose: To describe 7 eyes with severe infectious keratitis treated using collagen
crosslinking (CXL) with riboflavin. Materials and Methods: Seven eyes of 6 patients with …

Pathogen‐reduced platelets for the prevention of bleeding

LJ Estcourt, R Malouf, S Hopewell… - Cochrane Database …, 2017 - cochranelibrary.com
Background Platelet transfusions are used to prevent and treat bleeding in people who are
thrombocytopenic. Despite improvements in donor screening and laboratory testing, a small …

Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice

PI Johansson, J Stensballe, I Rosenberg… - …, 2007 - Wiley Online Library
BACKGROUND: Continued hemorrhage remains a major contributor of mortality in
massively transfused patients and those who survive have a higher platelet (PLT) count and …

Development of blood transfusion product pathogen reduction treatments: a review of methods, current applications and demands

V Salunkhe, PF Van der Meer, D de Korte… - … and Apheresis Science, 2015 - Elsevier
Transfusion-transmitted infections (TTI) have been greatly reduced in numbers due to the
strict donor selection and screening procedures, ie the availability of technologies to test …

Pathogen reduction of blood components

BG Solheim - Transfusion and apheresis science, 2008 - Elsevier
Thanks to many blood safety interventions introduced in developed countries the risk of
transfusion transmitted infections has become exceedingly small in these countries …

Toxicity testing of a novel riboflavin-based technology for pathogen reduction and white blood cell inactivation

HL Reddy, AD Dayan, J Cavagnaro, S Gad, J Li… - Transfusion medicine …, 2008 - Elsevier
The Mirasol PRT System (Gambro BCT, Lakewood, CO) for platelets and plasma uses
riboflavin and UV light to reduce pathogens and inactivate white blood cells in donated …

Preparation, storage and quality control of platelet concentrates

N Tynngård - Transfusion and apheresis science, 2009 - Elsevier
Patients with thrombocytopaenia need transfusions of platelet concentrates to prevent or
stop bleeding. A platelet transfusion should provide platelets with good functionality. The …

Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA)

K Makdoumi, A Bäckman, J Mortensen… - Graefe's Archive for …, 2010 - Springer
Background To evaluate the antibacterial efficacy of photo-activated riboflavin using
Ultraviolet A (UVA) on three bacterial strains commonly detected in keratitis. Methods Three …