IKAROS is a master regulator of cell fate determination in lymphoid and other hematopoietic
cells. This transcription factor orchestrates the association of epigenetic regulators with …

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk B-cell Acute
Lymphoblastic Leukemia (B-ALL) characterized by a gene expression profile similar to Ph …

Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target
genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros …

Background: Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a
promising therapeutic target in cancer. Recent studies have revealed an important role for …

Impaired function of the Ikaros (IKZF1) protein is associated with the development of high-
risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The mechanisms of Ikaros tumor …

Abstract Objective: The Myc proteins are transcription factors with essential roles in cell
growth and proliferation through their ability to regulate gene expression. MYC binding …

Ikaros is a zinc finger transcription factor (TF) of the Krüppel family member, which
significantly regulates normal lymphopoiesis and tumorigenesis. Ikaros can directly initiate …

The IKZF1 gene encodes the Ikaros protein, a zinc finger transcriptional factor that acts as a
master regulator of hematopoiesis and a tumor suppressor in leukemia. Impaired activity of …

Ikaros, encoded by IKZF1 (Ikaros family zinc finger 1), is an important transcription factor in
the control of lymphocyte specification and differentiation. Multiple functions of Ikaros have …

Signaling networks that regulate cellular proliferation often involve complex interactions
between several signaling pathways. In this manuscript we review the crosstalk between the …