Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell …

N Abdelaal, MA Ragheb, HM Hassaneen… - Scientific Reports, 2024 - nature.com
A novel series of six [1, 2, 4] triazolo [3, 4-a] isoquinolin-3-yl)-3-(1, 3-diphenyl-1 H-pyrazol-4-
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …

Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …

NS Ibrahim, HA Sayed, M Sharaky, HM Diab… - Naunyn-Schmiedeberg's …, 2024 - Springer
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …

[HTML][HTML] Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems

HM Diab, IA Abdelhamid, ME Salem, I Ragab… - Results in …, 2024 - Elsevier
Synthesis of analogs of known active compounds is the most often employed strategy for
producing important compounds. The Hantzsch reaction was employed to create new star …

Development of potential cathepsin B inhibitors: Synthesis of new bithiazole derivatives, in vitro studies supported with theoretical docking studies

S Yadav, C Vashisth, V Chaudhri, K Singh… - International Journal of …, 2024 - Elsevier
Cysteine cathepsins play a crucial role in cancer, inflammation, and the regulation of
degenerative processes such as apoptosis, making them significant targets in drug …

[PDF][PDF] Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules

HK Mahmoud, AHM Elwahy, IA Abdelhamid… - ARKIVOC., 2024 - arkat-usa.org
Piperazine and thiazole moieties are commonly found in medicines and bioactive
compounds. One of the fruitful ways in drug design is the hybridization of privilege structures …

[PDF][PDF] One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo [3', 2': 1, 2] pyrimido [4, 5-b] quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl …

RS Omar, AM Abdelmoniem, AHM Elwahy… - ARKIVOC, 2024 - arkat-usa.org
Abstract New thiazolo [3', 2': 1, 2] pyrimido [4, 5-b] quinolines were synthesized in good
yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and …

[PDF][PDF] Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules

ME Salem, HK Mahmoud, AHM Elwahy, IA Abdelhamid - ARKIVOC, 2024 - arkat-usa.org
Piperazine and thiazole moieties are commonly found in medicines and bioactive
compounds. One of the fruitful ways in drug design is the hybridization of privilege structures …