Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell …
N Abdelaal, MA Ragheb, HM Hassaneen… - Scientific Reports, 2024 - nature.com
A novel series of six [1, 2, 4] triazolo [3, 4-a] isoquinolin-3-yl)-3-(1, 3-diphenyl-1 H-pyrazol-4-
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …
Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
[HTML][HTML] Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems
Synthesis of analogs of known active compounds is the most often employed strategy for
producing important compounds. The Hantzsch reaction was employed to create new star …
producing important compounds. The Hantzsch reaction was employed to create new star …
Development of potential cathepsin B inhibitors: Synthesis of new bithiazole derivatives, in vitro studies supported with theoretical docking studies
S Yadav, C Vashisth, V Chaudhri, K Singh… - International Journal of …, 2024 - Elsevier
Cysteine cathepsins play a crucial role in cancer, inflammation, and the regulation of
degenerative processes such as apoptosis, making them significant targets in drug …
degenerative processes such as apoptosis, making them significant targets in drug …
[PDF][PDF] Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules
Piperazine and thiazole moieties are commonly found in medicines and bioactive
compounds. One of the fruitful ways in drug design is the hybridization of privilege structures …
compounds. One of the fruitful ways in drug design is the hybridization of privilege structures …
[PDF][PDF] One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo [3', 2': 1, 2] pyrimido [4, 5-b] quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl …
RS Omar, AM Abdelmoniem, AHM Elwahy… - ARKIVOC, 2024 - arkat-usa.org
Abstract New thiazolo [3', 2': 1, 2] pyrimido [4, 5-b] quinolines were synthesized in good
yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and …
yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and …
[PDF][PDF] Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules
Piperazine and thiazole moieties are commonly found in medicines and bioactive
compounds. One of the fruitful ways in drug design is the hybridization of privilege structures …
compounds. One of the fruitful ways in drug design is the hybridization of privilege structures …