[HTML][HTML] Emerging systemic JAK inhibitors in the treatment of atopic dermatitis: a review of abrocitinib, baricitinib, and upadacitinib

N Nezamololama, K Fieldhouse, K Metzger… - Drugs in …, 2020 - ncbi.nlm.nih.gov
The Janus kinases (JAK) are a group of molecules, composed of JAK1, JAK2, JAK3, and
tyrosine kinase 2 (TYK2), which are key components within the JAK–signal transducers and …

[HTML][HTML] Role of cytokines in vitiligo: pathogenesis and possible targets for old and new treatments

P Custurone, L Di Bartolomeo, N Irrera… - International journal of …, 2021 - mdpi.com
Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely
known. A wide variety of clinical studies have been proposed to investigate the immune …

[HTML][HTML] Melanoma and vitiligo: in good company

CM Failla, ML Carbone, C Fortes, G Pagnanelli… - International Journal of …, 2019 - mdpi.com
Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo
is an autoimmune disorder that leads to progressive destruction of skin melanocytes …

Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway

L Peng, Y Lu, Y Gu, B Liang, Y Li, H Li, Y Ke… - Pharmaceutical …, 2023 - Taylor & Francis
Context Vitiligo is a common skin disease with a complex pathogenesis, and so far, no
effective treatment is available. Lycium barbarum L.(Solanaceae) polysaccharide (LBP), the …

[HTML][HTML] MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo

J Huo, T Liu, F Li, X Song… - Molecular Medicine …, 2021 - spandidos-publications.com
Vitiligo (VIT) is caused by loss and degradation of functional epidermal melanocytes.
Studies have indicated that melanocyte destruction may be associated with an imbalance …

Research progress in small molecules as anti-vitiligo agents

H Wu, C Niu, HA Aisa - Current Medicinal Chemistry, 2024 - ingentaconnect.com
Vitiligo is a disease characterized by skin discoloration, and no safe and effective drugs
have been developed until now. New drug research and development are imminent. This …

[HTML][HTML] Statins role in vitiligo: A mini-review

HM Al-Kuraishy, NR Hussian, MS Al-Naimi… - Turkish Journal of …, 2020 - journals.lww.com
Vitiligo is a chronic acquired disease of pigmentation disorder. Melanocytes damage and
hypopigmentation relate to the induction of oxidative and autoimmune disorders. Different …

Cutaneous JAK expression in vitiligo

AA Abdel Motaleb, YM Tawfik… - Journal of …, 2021 - journals.sagepub.com
Background The Janus kinase–signal transducer and activator of transcription signaling
pathway has been suggested as a promising therapeutic target in vitiligo. However, limited …

Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis

NS Lai, HC Yu, HB Huang… - Mediators of …, 2023 - Wiley Online Library
This study aimed to identify the abnormal expression of long noncoding RNAs (lncRNAs) in
T cells from patients with vitiligo and to investigate their functional roles in the immune …

Cutaneous JAK Expression in Vitiligo.

AM AA, YM Tawfik, MA El-Mokhtar… - Journal of Cutaneous …, 2020 - europepmc.org
Background The Janus kinase-signal transducer and activator of transcription signaling
pathway has been suggested as a promising therapeutic target in vitiligo. However, limited …