Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Integrin-mediated attachment of epithelial cells to extracellular matrix (ECM) is crucial for
proper growth and survival. Although detachment leads to apoptosis, termed anoikis, recent …

Extracellular vesicles are emerging as a potent mechanism of intercellular communication
because they can systemically exchange genetic and protein material between cells …

The binding of integrin adhesion receptors to their extracellular matrix ligands controls cell
morphology, movement, survival, and differentiation in various developmental, homeostatic …

Cell growth and proliferation require coordinated ribosomal biogenesis and translation.
Eukaryotic initiation factors (eIFs) control translation at the rate-limiting step of initiation,. So …

Integrin signaling promotes, through p21-activated kinase, phosphorylation and inactivation
of the tumor suppressor merlin, thus removing a block to mitogenesis in normal cells …

The evidence for the importance of aberrant translation in cancer cells is overwhelming.
Reflecting the wealth of data, there are excellent reviews delineating how ribosomes and …

The mammalian target of rapamycin (mTOR) inhibitor CCI-779 (temsirolimus) is a recently
Food and Drug Administration–approved anticancer drug with efficacy in certain solid …

Summary Eukaryotic Initiation Factor 6 (eIF6) controls translation by regulating 80S subunit
formation. eIF6 is overexpressed in tumors. Here, we demonstrate that eIF6 inactivation …

Abstract Receptor for Activated C-Kinase 1 (RACK1) belongs to the WD40 family of proteins,
known to act as scaffolding proteins in interaction networks. Accordingly, RACK1 is found to …