Oncolytic viruses (OVs) are emerging as potentially useful platforms in treatment methods for
patients with tumors. They preferentially target and kill tumor cells, leaving healthy cells …

Over the last 60 years an eclectic collection of microbes has been tested in a variety of pre-
clinical models as anti-cancer agents. At the forefront of this research are a number of virus …

Oncolytic immunotherapy is a promising novel therapeutic for cancer, and further preclinical
studies may maximize its therapeutic efficacy. In this study, we construct a novel oncolytic …

Background Peritoneal carcinomatosis is a fatal clinical presentation of colon cancer,
characterized by unresponsiveness to conventional anticancer therapies, including immune …

Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

Tumors represent a hostile environment for the effector cells of cancer immunosurveillance.
Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly …

Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC)
patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the …

Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which
preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti …

Oncolytic virus (OV) therapy is an anti-cancer approach that uses viruses that preferentially
infect, replicate in and kill cancer cells. Vesicular stomatitis virus (VSV, a rhabdovirus) is an …

Background Central nervous system tumor (CNST) is one of the most complicated and lethal
forms of human tumors with very limited treatment options. In recent years, growing evidence …