Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
The gut microbial bile acid modulation and its relevance to digestive health and diseases
The human gut microbiome has been linked to numerous digestive disorders, but its
metabolic products have been much less well characterized, in part due to the expense of …
metabolic products have been much less well characterized, in part due to the expense of …
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Liquid chromatography-mass spectrometry (LC-MS) based untargeted metabolomics allows
to measure both known and unknown metabolites in the metabolome. However, unknown …
to measure both known and unknown metabolites in the metabolome. However, unknown …
Bacillus subtilis biofilm matrix components target seed oil bodies to promote growth and anti-fungal resistance in melon
MV Berlanga-Clavero, C Molina-Santiago… - Nature …, 2022 - nature.com
Beneficial microorganisms are used to stimulate the germination of seeds; however, their
growth-promoting mechanisms remain largely unexplored. Bacillus subtilis is commonly …
growth-promoting mechanisms remain largely unexplored. Bacillus subtilis is commonly …
Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
Elective transjugular intrahepatic portosystemic shunt (TIPS) placement can worsen
cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including …
cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including …
Comparison of cosine, modified cosine, and neutral loss based spectrum alignment for discovery of structurally related molecules
Spectrum alignment of tandem mass spectrometry (MS/MS) data using the modified cosine
similarity and subsequent visualization as molecular networks have been demonstrated to …
similarity and subsequent visualization as molecular networks have been demonstrated to …
MS/MS-based molecular networking accelerated discovery of germacrane-type sesquiterpene lactones from Elephantopus scaber L
W Xu, M Bai, DF Liu, SY Qin, TM Lv, Q Li, B Lin… - Phytochemistry, 2022 - Elsevier
Assisted by an MS/MS-based molecular networking guided strategy, six undescribed
germacrane-type sesquiterpene lactones, namely scaberxones AF, along with a known …
germacrane-type sesquiterpene lactones, namely scaberxones AF, along with a known …
The changing metabolic landscape of bile acids–keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …
maintain gut microbial community composition and mediate inflammation, and they serve as …
The underappreciated diversity of bile acid modifications
I Mohanty, H Mannochio-Russo, JV Schweer… - Cell, 2024 - cell.com
The repertoire of modifications to bile acids and related steroidal lipids by host and microbial
metabolism remains incompletely characterized. To address this knowledge gap, we …
metabolism remains incompletely characterized. To address this knowledge gap, we …
A multi-task FP-GNN framework enables accurate prediction of selective PARP inhibitors
PARP (poly ADP-ribose polymerase) family is a crucial DNA repair enzyme that responds to
DNA damage, regulates apoptosis, and maintains genome stability; therefore, PARP …
DNA damage, regulates apoptosis, and maintains genome stability; therefore, PARP …