Cyclic GMP-AMP synthase (cGAS) is a predominant and ubiquitously expressed cytosolic
onfirmedDNA sensor that activates innate immune responses by producing a second …

Abstract Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is
associated with various inflammatory diseases including systemic lupus erythematosus …

In addition to mitochondrial DNA, mitochondrial double-stranded RNA (mtdsRNA) is
exported from mitochondria. However, specific channels for RNA transport have not been …

TANK-binding kinase 1 (TBK1) is a member of the IKK family and plays a crucial role in the
activation of non-canonical NF-κB signaling and type I interferon responses. The aberrant …

Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition with limited
treatment options. Inflammation caused by metabolic disturbances plays a significant role in …

The evolutionary conserved DNA-sensing cGAS-STING innate immunity pathway represents
one of the most important cytosolic DNA-sensing systems that is activated in response to …