Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
[HTML][HTML] Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
B Gurdon, C Kaczorowski - Neurobiology of disease, 2021 - Elsevier
Alzheimer's disease (AD) is a complex disease that is mediated by numerous factors and
manifests in various forms. A systems biology approach to studying AD involves analyses of …
manifests in various forms. A systems biology approach to studying AD involves analyses of …
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline
Mitochondrial calcium overload contributes to neurodegenerative disease development and
progression. We recently reported that loss of the mitochondrial sodium/calcium exchanger …
progression. We recently reported that loss of the mitochondrial sodium/calcium exchanger …
LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and …
MM Grochowska, A Carreras Mascaro… - Acta …, 2021 - Springer
Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10)
gene have been associated with autosomal-dominant Parkinson's disease (PD), PD …
gene have been associated with autosomal-dominant Parkinson's disease (PD), PD …
[HTML][HTML] ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer's disease process
Alzheimer's disease (AD) accounts for approximately 60% of dementia cases worldwide.
Advanced age is the most significant risk factor for AD and approximately two-thirds of cases …
Advanced age is the most significant risk factor for AD and approximately two-thirds of cases …
Circuit-wide gene network analysis reveals sex-specific roles for phosphodiesterase 1b in cocaine addiction
Cocaine use disorder is a significant public health issue without an effective
pharmacological treatment. Successful treatments are hindered in part by an incomplete …
pharmacological treatment. Successful treatments are hindered in part by an incomplete …
Detecting differential transcript usage in complex diseases with SPIT
Differential transcript usage (DTU) plays a crucial role in determining how gene expression
differs among cells, tissues, and developmental stages, contributing to the complexity and …
differs among cells, tissues, and developmental stages, contributing to the complexity and …
Human brain organoids containing microglia that have arisen innately adapt to a β-amyloid challenge better than those in which microglia are integrated by co-culture
TJ Wenzel, JD Desjarlais, DD Mousseau - Stem Cell Research & Therapy, 2024 - Springer
Background Alzheimer disease (AD) is a heterogenous and multifactorial disease, and its
pathology is partly driven by microglia and their activated phenotype. Brain organoids (BOs) …
pathology is partly driven by microglia and their activated phenotype. Brain organoids (BOs) …
[HTML][HTML] Multi-omic integration reveals cell-type-specific regulatory networks of insulin resistance in distinct ancestry populations
Our knowledge of the cell-type-specific mechanisms of insulin resistance remains limited. To
dissect the cell-type-specific molecular signatures of insulin resistance, we performed a …
dissect the cell-type-specific molecular signatures of insulin resistance, we performed a …
Personalized Protein-Protein Interaction Networks Towards Unraveling the Molecular Mechanisms of Alzheimer's Disease
Alzheimer's disease (AD) is a highly heterogenous neurodegenerative disease, and several
omic-based datasets were generated in the last decade from the patients with the disease …
omic-based datasets were generated in the last decade from the patients with the disease …