Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Interactions between the microbiota and distal gut are fundamental determinants of human
health. Such interactions are concentrated at the colonic mucosa and provide energy for the …

HIF1α is a common component of pathways involved in the control of cellular metabolism
and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for …

Commensal interactions between the enteric microbiota and distal intestine play important
roles in regulating human health. Short-chain fatty acids (SCFAs), such as butyrate …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …

The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …

Background Systemic low-grade inflammation observed in diet-induced obesity has been
associated with dysbiosis and disturbance of intestinal homeostasis. This latter relies on an …