Biochemistry of nicotine metabolism and its relevance to lung cancer
SE Murphy - Journal of Biological Chemistry, 2021 - ASBMB
Nicotine is the key addictive constituent of tobacco. It is not a carcinogen, but it drives
smoking and the continued exposure to the many carcinogens present in tobacco. The …
smoking and the continued exposure to the many carcinogens present in tobacco. The …
[HTML][HTML] Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction
LA López-Flores, G Pérez-Rubio… - EXCLI …, 2017 - ncbi.nlm.nih.gov
Tobacco consumption has become a major public health issue, which has motivated studies
to identify and understand the biological processes involved in the smoking behavior for …
to identify and understand the biological processes involved in the smoking behavior for …
[HTML][HTML] Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: a case-control study and meta-analysis
Background Cervical cancer (CC) is the second most common type of female malignancy in
Bangladesh. Polymorphisms in the CYP1A1 gene have been reported to be associated with …
Bangladesh. Polymorphisms in the CYP1A1 gene have been reported to be associated with …
Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: a case-control study
Background Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two
deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and …
deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and …
CNTNAP2 gene polymorphisms in autism spectrum disorder and language impairment among Bangladeshi children: a case–control study combined with a meta …
Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder
characterized by communication deficits, impaired social interactions, repetitive and …
characterized by communication deficits, impaired social interactions, repetitive and …
CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers—findings from two independent populations
CA Wassenaar, Y Ye, Q Cai, MC Aldrich… - …, 2015 - academic.oup.com
We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African
American smokers, a high-risk population. Previously, we found that CYP2A6, a …
American smokers, a high-risk population. Previously, we found that CYP2A6, a …
DPYD* 2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer
Background Significant inter-individual variation in the sensitivity to 5-fluorouracil (5-FU)
represents a major therapeutic hindrance either by impairing drug response or inducing …
represents a major therapeutic hindrance either by impairing drug response or inducing …
Evaluation of risk factors for nasopharyngeal carcinoma in a high-risk area of India, the Northeastern Region
DS Lourembam, AR Singh, TD Sharma… - Asian Pacific Journal …, 2015 - koreascience.kr
Northeastern India is a major nasopharyngeal carcinoma (NPC) high risk-area although the
rest of the country has very low incidence. A case-control study of 105 NPC cases and 115 …
rest of the country has very low incidence. A case-control study of 105 NPC cases and 115 …
The ECCR1 rs11615, ERCC4 rs2276466, XPC rs2228000 and XPC rs2228001 polymorphisms increase the cervical cancer risk and aggressiveness in the …
Background Multiple studies around the world revealed that genetic polymorphism in
different genes of the DNA repair system might affect the DNA repair capabilities and …
different genes of the DNA repair system might affect the DNA repair capabilities and …
Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women
Pharmacogenomic studies play a significant role in understanding the risk of breast cancer
where genetic abnormalities are implicated as the etiology of cancer. Various …
where genetic abnormalities are implicated as the etiology of cancer. Various …