Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Clustering of proteins into micrometer-sized structures at membranes is observed in many
signaling pathways. Most models of clustering are specific to particular systems, and …

Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity,
represent a major health issue. However, they remain poorly understood. Here we have …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Almost all mammalian cell types have morphologies that are uniquely tailored to their
physiological functions. This immense variation in cell shape depends on an underlying …

Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …