Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Since the discovery of the low-density lipoprotein receptor (LDLR) and its association with
familial hypercholesterolemia in the early 1980s, a family of structurally related proteins has …

The major circulating form of vitamin D is 25-hydroxycholecalciferol [25 (OH) D3], which is
delivered to target tissues in complex with the serum vitamin D binding protein (DBP). We …

The mammalian epididymis is a highly coiled duct that links the efferent ducts to the vas
deferens. Overwhelming evidence points to the importance of this tissue in transforming …

Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (75–80
kDa). It was first linked to cell death in the rat ventral prostate after androgen deprivation …

There have been three major reviews dealing with structure and function of the efferent
ductules (Hamilton, 1975; Robaire and Hermo, 1988; Ilio and Hess, 1994). The first two …

Once shed from their fostering Sertoli cells, spermatozoa leave the testis and are transported
passively by seminiferous fluid through the rete testis. Then, these immature cells enter the …

The apolipoprotein (apo) E receptor-2 (apoER2) is a member of the low density lipoprotein
receptor gene family and an important regulator of neuronal migration. It acts as a receptor …

Megalin (LRP-2/GP330), a member of the LDL receptor family, is an endocytic receptor
expressed mainly in polarised epithelial cells. Identified as the pathogenic autoantigen of …

It is well known that high fluoride results in low fertility. Epididymis is the important place for
spermatozoa maturation, which is essential for successful fertilization. In the previous …