A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Astrocytes are the main support cells of the central nervous system. They also participate in
neuroimmune reactions. In response to pathological and immune stimuli, astrocytes …

Millions of urban children are chronically exposed to high concentrations of air pollutants, ie,
fine particulate matter (PM 2.5) and ozone, associated with increased risk for Alzheimer's …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the main cause of
dementia. The disease is among the leading medical concerns of the modern world …

Despite the remarkable complexity of the individual neuron and of neuronal circuits, it has
been clear for quite a while that, in order to understand the functioning of the brain, the …

Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its
instructive roles during development. Using developmental stage-sourced brain ECM in …

Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Studies
revealed that the pathogenesis of TBI involves upregulation of MMPs. MMPs form a large …

Evidence so far indicates that therapies targeting a single aspect of Alzheimer's disease
(AD) have no sufficient efficacy in diminishing long-term the progression of AD …

Early life Stress is a worldwide concern linked with development of later life neurological
disorders. Early developmental age is sensitive to many prominent environmental insults …

Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated
with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation …