Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …

Insects rely on a family of seven transmembrane proteins called gustatory receptors (GRs) to
encode different taste modalities, such as sweet and bitter. We report structures of …

The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …

Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …

Small-conductance Ca2+-activated K+ (SK) channels mediate neuron excitability and are
associated with synaptic transmission and plasticity. They also regulate immune responses …

Abstract Ca2+-activated, non-selective (CAN) ion channels sense increases of the
intracellular Ca2+ concentration, producing a flux of Na+ and/or K+ ions that depolarizes the …

Voltage-dependent ion channels regulate the opening of their pores by sensing the
membrane voltage. This process underlies the propagation of action potentials and other …