Many neurological diseases and delineating pathological regions have been analyzed, and
the anatomical structure of the brain researched with the aid of magnetic resonance imaging …

The modern era of drug development for A lzheimer's disease began with the proposal of
the cholinergic hypothesis of memory impairment and the 1984 research criteria for A …

Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

To study the impact of donepezil, rivastigmine, galantamine, and memantine on cognitive,
functional, behavioral, global changes and adverse effects in patients with mild, moderate …

Pharmacologic treatments for Alzheimer's disease include the cholinesterase inhibitors
donepezil, galantamine, and rivastigmine. We reviewed their evidence by searching …

BACKGROUND Alzheimer's disease (AD) is the most commonly occurring form of dementia.
It is predominantly a disease of later life, affecting 5% of those over 65 in the UK …

Introduction: Phosphodiesterase (PDE) inhibitors improve signaling pathways in brain
circuits by increasing intracellular cyclic adenosine monophosphate (cAMP) and/or cyclic …

Alzheimer's disease (AD) is characterized by cognitive inability manifested due to the
accumulation of β-amyloid, formation of hyper phosphorylated neurofibrillary tangles, and a …

During the last 20 years, an expanding body of research has elucidated the central role of
amyloid precursor protein (APP) processing and amyloid β peptide (Aβ) production in the …

Summary Abstract Memantine (Ebixa®, Axura®, Namenda®, Akatinol®) is a moderate-
affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off …