An improved understanding of stem cell niches, organogenesis, and disease models has
paved the way for developing a three-dimensional (3D) organoid culture system. Organoid …

SOX transcription factors are critical regulators of development, homeostasis and disease
progression and their dysregulation is a common finding in various cancers. SOX9 belongs …

Background & Aims A major clinical challenge for patients with pancreatic cancer (PC) is
metabolic adaptation. Neoplastic cells harboring molecular perturbations suffice for their …

Introduction Epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed,
and mutated in multiple cancers. In normal cell physiology, EGFR signaling controls cellular …

The epidermal growth factor receptor (EGFR) triggers the activation of many intracellular
signals that control cell proliferation, growth, survival, migration, and differentiation. Given its …

Background Patients with metastatic bladder cancer have very poor prognosis and
predictive biomarkers are urgently needed for early clinical detection and intervention. In this …

The forkhead box transcription factor A2 (FOXA2) is a transcription factor and plays a key
role in embryonic development, metabolism homeostasis and tumor cell proliferation; …

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer mainly owing to its
proclivity to early metastasis and the lack of effective targeted therapeutic drugs. Hence …

Abstract MUC16, membrane-bound mucin, plays an oncogenic role in pancreatic ductal
adenocarcinoma (PDAC). However, the pathological role of MUC16 in the PDAC …

Disease models enable researchers to investigate, test, and identify therapeutic targets that
would alter the patients' disease condition and improve quality of life. Advances in genetic …