Enzyme function initiative-enzyme similarity tool (EFI-EST): a web tool for generating protein sequence similarity networks
JA Gerlt, JT Bouvier, DB Davidson, HJ Imker… - … Et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract The Enzyme Function Initiative, an NIH/NIGMS-supported Large-Scale
Collaborative Project (EFI; U54GM093342; http://enzymefunction. org/), is focused on …
Collaborative Project (EFI; U54GM093342; http://enzymefunction. org/), is focused on …
[HTML][HTML] Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
InterPro in 2022
T Paysan-Lafosse, M Blum, S Chuguransky… - Nucleic acids …, 2023 - academic.oup.com
Abstract The InterPro database (https://www. ebi. ac. uk/interpro/) provides an integrative
classification of protein sequences into families, and identifies functionally important …
classification of protein sequences into families, and identifies functionally important …
The InterPro protein families and domains database: 20 years on
M Blum, HY Chang, S Chuguransky… - Nucleic acids …, 2021 - academic.oup.com
Abstract The InterPro database (https://www. ebi. ac. uk/interpro/) provides an integrative
classification of protein sequences into families, and identifies functionally important …
classification of protein sequences into families, and identifies functionally important …
The EFI web resource for genomic enzymology tools: leveraging protein, genome, and metagenome databases to discover novel enzymes and metabolic pathways
R Zallot, N Oberg, JA Gerlt - Biochemistry, 2019 - ACS Publications
The assignment of functions to uncharacterized proteins discovered in genome projects
requires easily accessible tools and computational resources for large-scale, user-friendly …
requires easily accessible tools and computational resources for large-scale, user-friendly …
InterPro in 2019: improving coverage, classification and access to protein sequence annotations
AL Mitchell, TK Attwood, PC Babbitt… - Nucleic acids …, 2019 - academic.oup.com
Abstract The InterPro database (http://www. ebi. ac. uk/interpro/) classifies protein
sequences into families and predicts the presence of functionally important domains and …
sequences into families and predicts the presence of functionally important domains and …
Computational identification of a systemic antibiotic for gram-negative bacteria
Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to
their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is …
their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is …
InterPro in 2017—beyond protein family and domain annotations
Abstract InterPro (http://www. ebi. ac. uk/interpro/) is a freely available database used to
classify protein sequences into families and to predict the presence of important domains …
classify protein sequences into families and to predict the presence of important domains …
Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics
INTRODUCTION Enzymes possess extraordinary catalytic proficiency and specificity. These
properties ultimately derive from interactions not just between the active-site residues and …
properties ultimately derive from interactions not just between the active-site residues and …
RadicalSAM. org: a resource to interpret sequence-function space and discover new radical SAM enzyme chemistry
N Oberg, TW Precord, DA Mitchell… - ACS bio & med chem …, 2021 - ACS Publications
The radical SAM superfamily (RSS), arguably the most functionally diverse enzyme
superfamily, is also one of the largest with∼ 700 K members currently in the UniProt …
superfamily, is also one of the largest with∼ 700 K members currently in the UniProt …