Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
Z Fang, Q Meng, J Xu, W Wang, B Zhang… - Cancer …, 2023 - Wiley Online Library
As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …
[HTML][HTML] Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming
Z Li, C Sun, Z Qin - Theranostics, 2021 - ncbi.nlm.nih.gov
Cancer cells are well-known for adapting their metabolism to maintain high proliferation
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
X Shi, J Yang, S Deng, H Xu, D Wu, Q Zeng… - Journal of Hematology & …, 2022 - Springer
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
Glutamine metabolism in breast cancer and possible therapeutic targets
S Li, H Zeng, J Fan, F Wang, C Xu, Y Li, J Tu… - Biochemical …, 2023 - Elsevier
Cancer is characterized by metabolic reprogramming, which is a hot topic in tumor treatment
research. Cancer cells alter metabolic pathways to promote their growth, and the common …
research. Cancer cells alter metabolic pathways to promote their growth, and the common …
Metabolic drivers of invasion in glioblastoma
Glioblastoma is a primary malignant brain tumor with a median survival under 2 years. The
poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape …
poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape …
Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment
Y Zhu, X Li, L Wang, X Hong, J Yang - Frontiers in Endocrinology, 2022 - frontiersin.org
It is notorious that cancer cells alter their metabolism to adjust to harsh environments of
hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor …
hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor …
Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling
HJ Kim, K Yang, K Kim, YJ Lee, S Lee… - Cellular & molecular …, 2022 - nature.com
The interplay between apoptotic cancer cells and the tumor microenvironment modulates
cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role …
cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role …
Akt isoforms: a family affair in breast cancer
A Basu, CB Lambring - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is the second leading cause of cancer-related death in
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …
α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis
Y Cai, L Lv, T Lu, M Ding, Z Yu, X Chen, X Zhou… - Cell Death …, 2023 - nature.com
Metabolic reprogramming is a hallmark of human malignancies. Dysregulation of glutamine
metabolism is essential for tumorigenesis, microenvironment remodeling, and therapeutic …
metabolism is essential for tumorigenesis, microenvironment remodeling, and therapeutic …
The role of cancer-associated fibroblasts in hepatocellular carcinoma and the value of traditional Chinese medicine treatment
W Jia, S Liang, B Cheng, C Ling - Frontiers in oncology, 2021 - frontiersin.org
Invasion and metastasis are the main reasons for the high mortality of liver cancer, which
involve the interaction of tumor stromal cells and malignant cells. Cancer-associated …
involve the interaction of tumor stromal cells and malignant cells. Cancer-associated …