Tuberculosis remains a major global health problem. Laboratory diagnostic methods that
allow effective, early detection of cases are central to management of tuberculosis in the …

Previously, we reported that a hygromycin resistant version of the BCGΔBCG1419c vaccine
candidate reduced tuberculosis (TB) disease in BALB/c, C57BL/6, and B6D2F1 mice …

A new series of sulfonamides, 8a-b, 10, 12, and 14a-b, were synthesized by N-sulfonation
reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16 …

Antimicrobial drug resistance creates major problems in the control of tuberculosis (TB).
Beijing and Haarlem genotypes of Mycobacterium tuberculosis are the prevalent genotypes …

In this study, a series of novel quinolinone-based thiosemicarbazones were designed in
silico and their activities tested in vitro against Mycobacterium tuberculosis (M. tuberculosis) …

Background: Transmission of Mycobacterium tuberculosis (M. tuberculosis) can occur in
different ways. Furthermore, drug resistant in M. tuberculosis family is a major problem that …

Background The insertion element IS 6110 is one of the main sources of genomic variability
in Mycobacterium tuberculosis, the etiological agent of human tuberculosis. Although IS …

An inability to standardize the bioinformatic data produced by whole-genome sequencing
(WGS) has been a barrier to its widespread use in tuberculosis phylogenetics. The aim of …

This investigation employed computational methodologies to assess the therapeutic
potential of derivatives (1–16) of pyridoxal isonicotinoyl hydrazone (PIH) as potential …

Background Tuberculosis remains a serious public health concern globally. The enormous
social, economic, and health impacts of the diseases are attributed to the lack of updated …