Selective estrogen receptor modulators (SERMs) are compounds that exhibit tissue-specific
estrogen receptor (ER) agonist or antagonist activity, and are used for various indications …

Estrogens regulate growth and development through the action of two distinct estrogen
receptors (ERs), ERα and ERβ, which mediate proliferation and differentiation of cells. For …

Steroid hormones are synthesized from cholesterol primarily in the adrenal gland and the
gonads and play vital roles in normal physiology, the control of development, differentiation …

The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding
protein 2 (IGF2BP1), binds to and stabilizes c-Myc, β-TrCP1, and other oncogenic mRNAs …

Breast cancer (BCa) is one of the most predominantly diagnosed cancers in women.
Notably, 70% of BCa diagnoses are Estrogen Receptor α positive (ERα+) making it a critical …

Because of their central importance in gene regulation and mediating the actions of many
hormones, the nuclear receptors (NRs) have long been recognized as very important …

Constitutive activation of NFκB in estrogen receptor (ER)-positive breast cancer is
associated with tumor recurrence and development of anti-estrogen resistance …

Therapeutic targeting of nuclear receptors (NRs) is presently restricted due to 2 constraints:
1) a limited knowledge of the structural dynamics of intact receptor when complexed to DNA …

Abstract In rodents, 17β-estradiol (E2) enhances hippocampal function and improves
performance in several memory tasks. Regarding the object recognition paradigm, E2 …

Nuclear signaling by estrogens rapidly induces the global recruitment of estrogen receptors
(ERs) to thousands of highly specific locations in the genome. Here, we have examined …