The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …
Integrins as biomechanical sensors of the microenvironment
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets
JJF Sleeboom, GS van Tienderen… - Science translational …, 2024 - science.org
The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …
Integrin activation by talin, kindlin and mechanical forces
Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …
extracellular matrix. They are essential for embryonic development and influence numerous …
Force spectroscopy of single cells using atomic force microscopy
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …
Single-molecule fluorescence microscopy review: shedding new light on old problems
S Shashkova, MC Leake - Bioscience reports, 2017 - portlandpress.com
Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse
technique offering exceptional contrast in conjunction with high specificity of labelling with …
technique offering exceptional contrast in conjunction with high specificity of labelling with …
Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second
N Strohmeyer, M Bharadwaj, M Costell, R Fässler… - Nature Materials, 2017 - nature.com
Integrin-mediated mechanosensing of the extracellular environment allows cells to control
adhesion and signalling. Whether cells sense and respond to force immediately upon ligand …
adhesion and signalling. Whether cells sense and respond to force immediately upon ligand …
The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells
The micro/nano hybrid structure is considered to be a biomaterial characteristic to stimulate
osteogenesis by mimicking the three-dimensional structure of the bone matrix. However, the …
osteogenesis by mimicking the three-dimensional structure of the bone matrix. However, the …
Integrin-ligand interactions in inflammation, cancer, and metabolic disease: Insights into the multifaceted roles of an emerging ligand irisin
Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …
Actin polymerization downstream of integrins: signaling pathways and mechanotransduction
A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to
migrate are dictated not only by soluble growth factors, but also through the direct interaction …
migrate are dictated not only by soluble growth factors, but also through the direct interaction …