Antibodies are among the most frequently used tools in basic science research and in
clinical assays, but there are no universally accepted guidelines or standardized methods …

In vitro display technologies, best exemplified by phage and yeast display, were first
described for the selection of antibodies some 20 years ago. Since then, many antibodies …

A wide variety of human malignancies exhibit sustained c-Met stimulation, overexpression,
or mutation, including carcinomas of the breast, liver, lung, ovary, kidney, and thyroid …

Abstract c-Met is a receptor tyrosine kinase that upon binding of its ligand, hepatocyte
growth factor (HGF), activates downstream pathways with diverse cellular functions that are …

Digital pathology and the adoption of image analysis have grown rapidly in the last few
years. This is largely due to the implementation of whole slide scanning, advances in …

This year, 2008, marks the 10-year anniversary of the development of the modern tissue
microarray (TMA). During the last decade, the use of TMAs has grown steadily and accounts …

Antibody conjugates are widely used as diagnostics and imaging reagents. However, many
such conjugates suffer losses in sensitivity and specificity due to nonspecific labeling …

Triple negative breast cancer (TNBC) accounts for 10–20% of cases in breast cancer.
Despite recent advances in the treatment of hormonal receptor+ and HER2+ breast cancers …

The multibillion-dollar global antibody industry produces an indispensable resource but that
is generated using millions of animals. Despite the irrefutable maturation and availability of …

Antibodies are indispensable research reagents. Their use in endocrinology has exploded
since the original radioimmunoassays were developed to measure hormone levels. They …