[HTML][HTML] NMR spectroscopy for metabolomics research

AH Emwas, R Roy, RT McKay, L Tenori, E Saccenti… - Metabolites, 2019 - mdpi.com
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Two‐dimensional J‐resolved NMR spectroscopy: review of a key methodology in the metabolomics toolbox

C Ludwig, MR Viant - Phytochemical Analysis: An International …, 2010 - Wiley Online Library
Abstract One‐dimensional (1D) 1H NMR spectroscopy remains a leading analytical
technology in metabolomics. Advantages of this approach include relatively rapid spectral …

[PDF][PDF] Accelerated NMR spectroscopy by using compressed sensing

K Kazimierczuk, VY Orekhov - Angewandte Chemie, 2011 - researchgate.net
There is increased interest in high-resolution, fast multidimensional NMR spectroscopy for
studying molecular structure, interactions, and dynamics. The distinct feature of the …

Atomic-resolution chemical characterization of (2x)72-kDa tryptophan synthase via four- and five-dimensional 1H-detected solid-state NMR

A Klein, P Rovó, VV Sakhrani, Y Wang… - Proceedings of the …, 2022 - National Acad Sciences
NMR chemical shifts provide detailed information on the chemical properties of molecules,
thereby complementing structural data from techniques like X-ray crystallography and …

13C Direct Detected NMR for Challenging Systems

IC Felli, R Pierattelli - Chemical Reviews, 2022 - ACS Publications
Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

Multivalency regulates activity in an intrinsically disordered transcription factor

S Clark, JB Myers, A King, R Fiala, J Novacek… - Elife, 2018 - elifesciences.org
The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of
recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1) …

Random sampling in multidimensional NMR spectroscopy

K Kazimierczuk, J Stanek… - Progress in nuclear …, 2010 - Elsevier
Nuclear Magnetic Resonance (NMR) is nowadays one of the most efficient spectroscopic
techniques, providing insight into molecular structure and dynamics. The sources of the …

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin

A Sponga, JL Arolas, TC Schwarz, CM Jeffries… - Science …, 2021 - science.org
In sarcomeres, α-actinin cross-links actin filaments and anchors them to the Z-disk. FATZ
(filamin-, α-actinin-, and telethonin-binding protein of the Z-disk) proteins interact with α …

Unambiguous side-chain assignments for solid-state NMR structure elucidation of Nondeuterated Proteins via a combined 5D/4D side-chain-to-backbone experiment

A Klein, SK Vasa, B Söldner, K Grohe… - The Journal of Physical …, 2022 - ACS Publications
Owing to fast-magic-angle-spinning technology, proton-detected solid-state NMR has been
facilitating the analysis of insoluble, crystalline, sedimented, and membrane proteins …

[HTML][HTML] Sequence context influences the structure and aggregation behavior of a PolyQ tract

B Eftekharzadeh, A Piai, G Chiesa, D Mungianu… - Biophysical journal, 2016 - cell.com
Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of
neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential …