Nanoparticle-based anticancer medications were first approved for cancer treatment almost
2 decades ago. Patients benefit from these approaches because of the targeted-drug …

Complement is integral to a healthy functioning immune system and orchestrates various
innate and adaptive responses against viruses and other pathogens. Despite its importance …

Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

It is estimated that one million deaths per year are caused by mosquito-borne diseases
worldwide. While preventing such diseases is possible and, of course, more manageable …

Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Basigin is an essential host receptor for invasion of Plasmodium falciparum into human
erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage …

The Plasmodium falciparum circumsporozoite protein (CSP) forms the basis of leading
subunit malaria vaccine candidates. However, the mechanisms and specific targets of …

Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …

The induction of protective humoral immune responses against sporozoite surface proteins
of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a …

Background Protective malarial antibodies are acquired more rapidly in adults than children,
independently of cumulative exposure, however the cellular responses mediating these …