Model systems for regeneration: planarians

M Ivankovic, R Haneckova, A Thommen… - …, 2019 - journals.biologists.com
Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics

M Plass, J Solana, FA Wolf, S Ayoub, A Misios… - Science, 2018 - science.org
INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

Nervous system development and regeneration in freshwater planarians

KG Ross, KW Currie, BJ Pearson… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Planarians have a long history in the fields of developmental and regenerative biology.
These animals have also sparked interest in neuroscience due to their neuroanatomy …

Sequenceserver: a modern graphical user interface for custom BLAST databases

A Priyam, BJ Woodcroft, V Rai, I Moghul… - Molecular biology …, 2019 - academic.oup.com
Comparing newly obtained and previously known nucleotide and amino-acid sequences
underpins modern biological research. BLAST is a well-established tool for such …

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

MA Grohme, S Schloissnig, A Rozanski, M Pippel… - Nature, 2018 - nature.com
The planarian Schmidtea mediterranea is an important model for stem cell research and
regeneration, but adequate genome resources for this species have been lacking. Here we …

PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity

A Rozanski, HK Moon, H Brandl… - Nucleic acids …, 2019 - academic.oup.com
Flatworms (Platyhelminthes) are a basally branching phylum that harbours a wealth of
fascinating biology, including planarians with their astonishing regenerative abilities and the …

Evolutionary dynamics of whole-body regeneration across planarian flatworms

M Vila-Farré, A Rozanski, M Ivanković… - Nature ecology & …, 2023 - nature.com
Regenerative abilities vary dramatically across animals. Even amongst planarian flatworms,
well-known for complete regeneration from tiny body fragments, some species have …

A planarian nidovirus expands the limits of RNA genome size

A Saberi, AA Gulyaeva, JL Brubacher… - PLoS …, 2018 - journals.plos.org
RNA viruses are the only known RNA-protein (RNP) entities capable of autonomous
replication (albeit within a permissive host environment). A 33.5 kilobase (kb) nidovirus has …

Island-specific evolution of a sex-primed autosome in a sexual planarian

L Guo, JS Bloom, D Dols-Serrate, J Boocock… - Nature, 2022 - nature.com
The sexual strain of the planarian Schmidtea mediterranea, indigenous to Tunisia and
several Mediterranean islands, is a hermaphrodite,. Here we isolate individual …

Antagonistic self-organizing patterning systems control maintenance and regeneration of the anteroposterior axis in planarians

T Stückemann, JP Cleland, S Werner, HTK Vu… - Developmental cell, 2017 - cell.com
Planarian flatworms maintain their body plan in the face of constant internal turnover and
can regenerate from arbitrary tissue fragments. Both phenomena require self-maintaining …