Emerging tick-borne diseases

S Madison-Antenucci, LD Kramer… - Clinical microbiology …, 2020 - Am Soc Microbiol
Increases in tick-borne disease prevalence and transmission are important public health
issues. Efforts to control these emerging diseases are frustrated by the struggle to control tick …

Lyme borreliosis

AC Steere, F Strle, GP Wormser, LT Hu… - Nature reviews Disease …, 2016 - nature.com
Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of
the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in …

Recent progress in Lyme disease and remaining challenges

JR Bobe, BL Jutras, EJ Horn, ME Embers… - Frontiers in …, 2021 - frontiersin.org
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …

[HTML][HTML] Current guidelines, common clinical pitfalls, and future directions for laboratory diagnosis of Lyme disease, United States

A Moore, C Nelson, C Molins, P Mead… - Emerging infectious …, 2016 - ncbi.nlm.nih.gov
Abstract In the United States, Lyme disease is caused by Borrelia burgdorferi and
transmitted to humans by blacklegged ticks. Patients with an erythema migrans lesion and …

Lyme borreliosis diagnosis: State of the art of improvements and innovations

M Guérin, M Shawky, A Zedan, S Octave, B Avalle… - BMC microbiology, 2023 - Springer
With almost 700 000 estimated cases each year in the United States and Europe, Lyme
borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the …

Discovery and surveillance of tick-borne pathogens

R Tokarz, WI Lipkin - Journal of Medical Entomology, 2021 - academic.oup.com
Within the past 30 yr molecular assays have largely supplanted classical methods for
detection of tick-borne agents. Enhancements provided by molecular assays, including …

Laboratory diagnosis of Lyme borreliosis

JA Branda, AC Steere - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Lyme borreliosis is caused by a growing list of related, yet distinct, spirochetes with complex
biology and sophisticated immune evasion mechanisms. It may result in a range of clinical …

Variable selection in omics data: A practical evaluation of small sample sizes

A Kirpich, EA Ainsworth, JM Wedow, JRB Newman… - PloS one, 2018 - journals.plos.org
In omics experiments, variable selection involves a large number of metabolites/genes and
a small number of samples (the n< p problem). The ultimate goal is often the identification of …

Longitudinal transcriptome analysis reveals a sustained differential gene expression signature in patients treated for acute Lyme disease

J Bouquet, MJ Soloski, A Swei, C Cheadle… - MBio, 2016 - Am Soc Microbiol
Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi, and
approximately 10 to 20% of patients report persistent symptoms lasting months to years …

The past, present, and (possible) future of serologic testing for Lyme disease

ES Theel - Journal of Clinical Microbiology, 2016 - Am Soc Microbiol
Lyme disease prevails as the most commonly transmitted tick-borne infection in the United
States, and serologic evaluation for antibodies to Borrelia burgdorferi remains the …