Type II DNA topoisomerases have the ability to generate a transient DNA double-strand
break through which a second duplex can be passed; an activity essential for DNA …

Topoisomerase poisons such as the epipodophyllotoxin etoposide are widely used effective
cytotoxic anticancer agents. However, they are associated with the development of therapy …

Two isoforms of DNA topoisomerase II (topo II) have been identified in mammalian cells.
While topo IIα is essential for chromosome segregation in mitotic cells, in vivofunction of topo …

The effects of the inhibitors of topoisomerase I and II, camptothecin and etoposide, as well
as novobiocin and adriamycin, on the DNA fragmentation and viability of mouse thymocytes …

Publisher Summary Oncogenes play an important role in the regulation of cellular resistance
to ionizing radiation. This chapter reviews some of that evidence and attempt to formulate …

The discovery of molecular and cellular mechanisms of pathology, together with the present
data on drug treatment result in enhanced drug design and testing. The known mechanisms …

Regulation of topoisomerase II (TOPO II) isozymes and β is influenced by the growth and
transformation state of cells. Using HL-60 cells induced to differentiate by all-trans retinoic …

Topoisomerase II has been suggested to have a role in the early events of differentiation.
This possibility was evaluated by measuring the effects of inhibitors of topoisomerase II on …

The potential of a combination of differentiation induction and chemotherapy was analyzed.
Treatment of the murine embryonal carcinoma (EC) cell line PCC4 in vitro with all …

The simple elegance of the antiparallel, plectonemic DNA double helix revealed by Watson,
Crick and Wilkins gave substance to the concept of DNA as a repository of genetic …