Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials

MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2017 - Elsevier
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued
development and standardization of methodologies for biomarkers and has provided an …

Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment

G Lombardi, G Crescioli, E Cavedo… - Cochrane Database …, 2020 - cochranelibrary.com
Background Mild cognitive impairment (MCI) due to Alzheimer's disease is the symptomatic
predementia phase of Alzheimer's disease dementia, characterised by cognitive and …

New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer's disease

SA Park, SM Han, CE Kim - Experimental & molecular medicine, 2020 - nature.com
Cerebrospinal fluid (CSF) biomarkers based on the core pathological proteins associated
with Alzheimer's disease (AD), ie, amyloid-β (Aβ) and tau protein, are widely regarded as …

Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease

O Libiger, LM Shaw, MH Watson… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction: Biomarkers that reflect pathologic processes affecting neuronal function during
preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug …

Predicting the progression of mild cognitive impairment using machine learning: a systematic, quantitative and critical review

M Ansart, S Epelbaum, G Bassignana, A Bône… - Medical Image …, 2021 - Elsevier
We performed a systematic review of studies focusing on the automatic prediction of the
progression of mild cognitive impairment to Alzheimer's disease (AD) dementia, and a …

A comprehensive systematic review of CSF proteins and peptides that define Alzheimer's disease

CM Pedrero-Prieto, S García-Carpintero… - Clinical Proteomics, 2020 - Springer
Background During the last two decades, over 100 proteomics studies have identified a
variety of potential biomarkers in CSF of Alzheimer's (AD) patients. Although several reviews …

Oxidative damage of DNA as early marker of Alzheimer's disease

C Peña-Bautista, T Tirle, M López-Nogueroles… - International journal of …, 2019 - mdpi.com
Alzheimer's Disease (AD) is the most common cause of dementia, and its characteristic
histopathological hallmarks are neurofibrillary tangles and senile plaques. Among involved …

Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer's disease: a literature review

KEJ Wesenhagen, CE Teunissen… - Critical reviews in …, 2020 - Taylor & Francis
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
aggregation of amyloid and tau proteins in the brain. Results from genetic studies suggest …

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's …

RW Paterson, WE Heywood, AJ Heslegrave… - Translational …, 2016 - nature.com
Alzheimer's disease (AD) is the most common cause of dementia. Biomarkers are required
to identify individuals in the preclinical phase, explain phenotypic diversity, measure …

Key inflammatory pathway activations in the MCI stage of Alzheimer's disease

JA Pillai, S Maxwell, J Bena, LM Bekris… - Annals of Clinical …, 2019 - Wiley Online Library
Objective To determine the key inflammatory pathways that are activated in the peripheral
and CNS compartments at the mild cognitive impairment (MCI) stage of Alzheimer's disease …