[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
The science and medicine of human immunology
B Pulendran, MM Davis - Science, 2020 - science.org
BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …
detection and neutralization of pathogens. History is replete with the devastating effects of …
Bioinformatics challenges for genome-wide association studies
Motivation: The sequencing of the human genome has made it possible to identify an
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …
A computationally fast variable importance test for random forests for high-dimensional data
S Janitza, E Celik, AL Boulesteix - Advances in Data Analysis and …, 2018 - Springer
Random forests are a commonly used tool for classification and for ranking candidate
predictors based on the so-called variable importance measures. These measures attribute …
predictors based on the so-called variable importance measures. These measures attribute …
[HTML][HTML] A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination
RJM Engler, MR Nelson, LC Collins Jr, C Spooner… - PloS one, 2015 - journals.plos.org
Background Although myocarditis/pericarditis (MP) has been identified as an adverse event
following smallpox vaccine (SPX), the prospective incidence of this reaction and new onset …
following smallpox vaccine (SPX), the prospective incidence of this reaction and new onset …
[HTML][HTML] Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses
Background The genesis of severe fatigue and disability in people following acute pathogen
invasion involves the activation of Toll-like receptors followed by the upregulation of …
invasion involves the activation of Toll-like receptors followed by the upregulation of …
[HTML][HTML] Application of machine learning in translational medicine: current status and future opportunities
N Terranova, K Venkatakrishnan, LJ Benincosa - The AAPS Journal, 2021 - Springer
The exponential increase in our ability to harness multi-dimensional biological and clinical
data from experimental to real-world settings has transformed pharmaceutical research and …
data from experimental to real-world settings has transformed pharmaceutical research and …
Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes
EM Savilahti, V Rantanen, JS Lin, S Karinen… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: The dynamics and balance of allergen-specific IgE, IgG4, and IgA binding
might contribute to the development of tolerance in patients with cow's milk allergy (CMA) …
might contribute to the development of tolerance in patients with cow's milk allergy (CMA) …
Systems vaccinology: enabling rational vaccine design with systems biological approaches
Vaccines have drastically reduced the mortality and morbidity of many diseases. However,
vaccines have historically been developed empirically, and recent development of vaccines …
vaccines have historically been developed empirically, and recent development of vaccines …
[HTML][HTML] Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population
The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools.
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …