Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood
pressure and may be a causative factor in essential hypertension. The extracellular matrix …

Arteries exhibit a remarkable ability to adapt to diverse genetic defects and sustained
alterations in mechanical loading. For example, changes in blood flow induced wall shear …

The stiffness and structural integrity of the arterial wall depends primarily on the organization
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …

The abdominal aorta (AA) in older individuals can develop an aneurysm, which is of
increasing concern in our ageing population. The structural integrity of the ageing aortic …

Aims Elastin is the primary component of elastic fibres in arteries, which contribute
significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that …

Central artery stiffness has emerged over the past 15 years as a clinically significant
indicator of cardiovascular function and initiator of disease. Loss of elastic fiber integrity is …

Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …

Tissue-engineered blood vessels (TEVs) are typically produced using the pulsatile, uniaxial
circumferential stretch to mechanically condition and strengthen the arterial grafts. Despite …

Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief
among them mutations to the gene that encodes fibrillin-1 and leads to Marfan syndrome …

Arteries experience marked variations in blood pressure and flow during the cardiac cycle
that can intensify during exercise, in disease, or with aging. Diverse observations …