Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …

Pathfinding by growing axons in the developing or regenerating nervous system is guided
by gradients of molecular guidance cues. The neuronal growth cone, located at the ends of …

Filopodia are thin cellular protrusions that are important in cell motility and neuronal growth
cone guidance. The actin filaments that make up the core of a filopodium undergo …

Neurons transport and position mitochondria using a combination of saltatory, bidirectional
movements and stationary docking. Axonal mitochondria move along microtubules (MTs) …

Myosin VI (Myo6) is an actin-based motor protein implicated in clathrin-mediated
endocytosis in nonneuronal cells, though little is known about its function in the nervous …

Neuronal growth cones are exquisite sensory-motor machines capable of transducing
features contacted in their local extracellular environment into guided process extension …

Growth cones are required for the forward advancement and navigation of growing axons.
Modulation of growth cone shape and reorientation of the neurite are responsible for the …

Members of the myosin superfamily are involved in all aspects of eukaryotic life. Their
function ranges from the transport of organelles and cargos to the generation of membrane …

Myosin VI is the only type of myosin motor known to move toward the minus ends of actin
filaments. This reversal in the direction of its movement is in part a consequence of the …