[HTML][HTML] Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
DNA repair mechanisms in dividing and non-dividing cells
T Iyama, DM Wilson III - DNA repair, 2013 - Elsevier
DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …
forms, and if allowed to persist, can promote genome instability and directly lead to various …
[HTML][HTML] The mitochondrial response to DNA damage
Z Rong, P Tu, P Xu, Y Sun, F Yu, N Tu… - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …
The maintenance of mitochondrial DNA integrity—critical analysis and update
M Alexeyev, I Shokolenko… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …
Protecting the mitochondrial powerhouse
Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu
for the synthesis of many essential molecules and allow for highly efficient energy …
for the synthesis of many essential molecules and allow for highly efficient energy …
Minimizing the damage: repair pathways keep mitochondrial DNA intact
Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …
accurate replication, transmission and preservation of its integrity throughout the life of the …
Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2)
TDP1 and TDP2 were discovered and named based on the fact they process 3′-and 5′-
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …
DNA repair deficiency in neurodegeneration
DK Jeppesen, VA Bohr, T Stevnsner - Progress in neurobiology, 2011 - Elsevier
Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …
PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
Abstract Poly (ADP-ribose) polymerases (PARP) attach poly (ADP-ribose)(PAR) chains to
various proteins including themselves and chromatin. Topoisomerase I (Top1) regulates …
various proteins including themselves and chromatin. Topoisomerase I (Top1) regulates …