Proteases in parasitic diseases

JH McKerrow, C Caffrey, B Kelly… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Parasitic diseases represent major global health problems of immense proportion.
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness …

Malarial proteases and host cell egress: an 'emerging'cascade

MJ Blackman - Cellular microbiology, 2008 - Wiley Online Library
Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort
to better understand the biology of its aetiological agent. Like all pathogens of the phylum …

Reconciliation with non-binary species trees

B Vernot, M Stolzer, A Goldman… - Journal of computational …, 2008 - liebertpub.com
Reconciliation extracts information from the topological incongruence between gene and
species trees to infer duplications and losses in the history of a gene family. The inferred …

Loss of the flagellum happened only once in the fungal lineage: phylogenetic structure of kingdom Fungi inferred from RNA polymerase II subunit genes

YJ Liu, MC Hodson, BD Hall - BMC Evolutionary Biology, 2006 - Springer
Background At present, there is not a widely accepted consensus view regarding the
phylogenetic structure of kingdom Fungi although two major phyla, Ascomycota and …

An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum

M Asad, Y Yamaryo-Botté, ME Hossain, V Thakur… - BMC biology, 2021 - Springer
Background Plasmodium falciparum is the pathogen responsible for the most devastating
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …

Plasmodium falciparum SERA5 plays a non‐enzymatic role in the malarial asexual blood‐stage lifecycle

R Stallmach, M Kavishwar… - Molecular …, 2015 - Wiley Online Library
The malaria parasite P lasmodium falciparum replicates in an intraerythrocytic
parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA 5 …

Position of human blood group O (H) and phenotype‐determining enzymes in growth and infectious disease

P Arend - Annals of the New York Academy of Sciences, 2018 - Wiley Online Library
The human ABO (H) blood group phenotypes arise from the evolutionarily oldest genetic
system found in primate populations. While the blood group antigen A is considered the …

Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red Blood Cells and Their Implications for Vaccine Design

LE Rodriguez, H Curtidor, M Urquiza… - Chemical …, 2008 - ACS Publications
Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red
Blood Cells and Their Implications for Vaccine Design | Chemical Reviews ACS ACS …

Evidence for a Common Role for the Serine-Type Plasmodium falciparum Serine Repeat Antigen Proteases: Implications for Vaccine and Drug Design

JE McCoubrie, SK Miller, T Sargeant… - Infection and …, 2007 - Am Soc Microbiol
Serine repeat antigens (SERAs) are a family of secreted “cysteine-like” proteases of
Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in …

Alteration of the parasite plasma membrane and the parasitophorous vacuole membrane during exo-erythrocytic development of malaria parasites

A Sturm, S Graewe, B Franke-Fayard, S Retzlaff… - Protist, 2009 - Elsevier
The rodent malaria parasite Plasmodium berghei develops in hepatocytes within 48–52h
from a single sporozoite into up to 20,000 daughter parasites, so-called merozoites. The …