We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing
aggregated Aβ from the brains of symptomatic patients can slow the progression of …

Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term,
lack of sleep leads to impaired memory and attention; in the longer term, it produces …

Cerebral vessels are composed of highly complex structures that facilitate blood perfusion
necessary for meeting the high energy demands of the brain. Their geometrical complexities …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute
transport and the exchange of brain waste products. CSF flow is thus important for brain …

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …

Neurofluids is a term introduced to define all fluids in the brain and spine such as blood,
cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …