ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …

Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …

In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1), also referred to as ADP-
ribosyltransferase Diphtheria toxin-like 1 (ARTD1), is an abundant nuclear protein that plays …

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

Poly (ADP-ribose) polymerase 1 (PARP-1) regulates gene transcription, cell death signaling,
and DNA repair through production of the posttranslational modification poly (ADP-ribose) …

Abstract Poly (ADP-ribose) Polymerase1 (PARP1) is a member of 17 membered PARP
family having diversified biological functions such as synthetic lethality, DNA repair …