Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …

More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory
and activation receptors for major histocompatibility complex class I molecules as a means …

Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

The T-cell biology of the liver is unlike that of any other organ. The local lymphocyte
population is enriched in natural killer (NK) and NKT cells, which might have crucial roles in …

The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

Despite high expression levels at the plasma membrane or in intracellular vesicles,
tetraspanins remain among the most mysterious transmembrane molecules 20 years after …

To define the early events that determine the outcome of acute hepatitis C virus (HCV)
infection, we compared the course of viremia with the peripheral and intrahepatic T cell …