Optic nerve degeneration after retinal ischemia/reperfusion in a rodent model

M Renner, G Stute, M Alzureiqi, J Reinhard… - Frontiers in cellular …, 2017 - frontiersin.org
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-
related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular …

Extending injury-and disease-resistant CNS phenotypes by repetitive epigenetic conditioning

JM Gidday - Frontiers in neurology, 2015 - frontiersin.org
Significant reductions in the extent of acute injury in the CNS can be achieved by exposure
to different preconditioning stimuli, but the duration of the induced protective phenotype is …

From ganglion cell to photoreceptor layer: timeline of deterioration in a rat ischemia/reperfusion model

M Palmhof, V Frank, P Rappard… - Frontiers in cellular …, 2019 - frontiersin.org
Neuronal damage and impaired vision in different retinal disorders are induced, among
other factors, by ischemia/reperfusion (I/R). Since the mechanisms and the progression of …

[HTML][HTML] Adaptive plasticity in the retina: Protection against acute injury and neurodegenerative disease by conditioning stimuli

JM Gidday - Conditioning medicine, 2018 - ncbi.nlm.nih.gov
Although both preclinical and clinical conditioning studies in heart and brain lead the field of
conditioning medicine, investigations of retinal conditioning still number more than 100. In …

Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression

Y Pang, M Qin, P Hu, K Ji, R Xiao… - International …, 2020 - spandidos-publications.com
Loss of idiopathic retinal ganglion cells (RGCs) leads to irreversible vision defects and is
considered the primary characteristic of glaucoma. However, effective treatment strategies in …

Resveratrol protects retinal ganglion cell axons through regulation of the SIRT1-JNK pathway

Y Wu, Y Pang, W Wei, A Shao, C Deng, X Li… - Experimental Eye …, 2020 - Elsevier
It is reported that Ischemia and reperfusion damage (I/R damage) can lead to retinal
ganglion cell (RGC) death and neurodegeneration, which in turn can lead to irreversible …

Knock-out of tenascin-C ameliorates ischemia-induced rod-photoreceptor degeneration and retinal dysfunction

S Wiemann, A Yousf, SC Joachim, C Peters… - Frontiers in …, 2021 - frontiersin.org
Retinal ischemia is a common pathomechanism in various eye diseases. Recently,
evidence accumulated suggesting that the extracellular matrix (ECM) glycoprotein tenascin …

Fewer functional deficits and reduced cell death after ranibizumab treatment in a retinal ischemia model

M Palmhof, S Lohmann, D Schulte, G Stute… - International Journal of …, 2018 - mdpi.com
Retinal ischemia is an important factor in several eye disorders. To investigate the impact of
VEGF inhibitors, as a therapeutic option, we studied these in a retinal ischemia animal …

Remote ischemic postconditioning promotes the survival of retinal ganglion cells after optic nerve injury

X Liu, O Sha, EYP Cho - Journal of Molecular Neuroscience, 2013 - Springer
Ischemic conditioning, the application of a mild ischemic stimulus to an ischemia-sensitive
structure like the heart or brain either before (preconditioning) or after (postconditioning) its …

Experimental optic neuritis induced by the microinjection of lipopolysaccharide into the optic nerve

ML Aranda, D Dorfman, PH Sande… - Experimental …, 2015 - Elsevier
Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal
injury in the optic nerve which leads to retinal ganglion cell (RGC) loss, and visual …