Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
TH Baryakova, BH Pogostin, R Langer… - Nature Reviews Drug …, 2023 - nature.com
Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …
socioeconomic consequences. Although the underlying reasons are generally understood …
Materials and structure of polysaccharide-based delivery carriers for oral insulin: A review
X Wang, H Sun, T Mu - Carbohydrate Polymers, 2023 - Elsevier
Diabetes mellitus is a chronic metabolic disease that affects> 500 million patients worldwide.
Subcutaneous injection of insulin is the most effective treatment at present. However, regular …
Subcutaneous injection of insulin is the most effective treatment at present. However, regular …
Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch
Z Luo, D Klein Cerrejon, S Römer, N Zoratto… - Science Translational …, 2023 - science.org
Biopharmaceuticals, including proteins and peptides, have revolutionized the treatment of a
wide range of diseases, from diabetes and cardiovascular disorders to virus infections and …
wide range of diseases, from diabetes and cardiovascular disorders to virus infections and …
Proof-of-concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid
As the SARS-CoV-2 virus continues to spread and mutate, it remains important to focus not
only on preventing spread through vaccination but also on treating infection with direct …
only on preventing spread through vaccination but also on treating infection with direct …
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery
I Ramirez-Velez, B Belardi - Advanced drug delivery reviews, 2023 - Elsevier
As biologics used in the clinic outpace the number of new small molecule drugs, an
important challenge for their efficacy and widespread use has emerged, namely tissue …
important challenge for their efficacy and widespread use has emerged, namely tissue …
Affordable oral proinsulin bioencapsulated in plant cells regulates blood sugar levels similar to natural insulin
Diabetes Mellitus is a silent epidemic affecting> 500 million, which claimed 6.7 million lives
in 2021, a projected increase of> 670% in< 20 years old in the next two decades but insulin …
in 2021, a projected increase of> 670% in< 20 years old in the next two decades but insulin …
Preparation, drug distribution, and in vivo evaluation of the safety of protein corona liposomes for liraglutide delivery
R Ding, Z Zhao, J He, Y Tao, H Zhang, R Yuan, K Sun… - Nanomaterials, 2023 - mdpi.com
The development of oral drug delivery systems is challenging, and issues related to the
mucus layer and low intestinal epithelial permeability have not yet been surmounted. The …
mucus layer and low intestinal epithelial permeability have not yet been surmounted. The …
Managing diabetes with hydrogel drug delivery
Diabetes is one of the most pressing healthcare challenges facing society. Dysfunctional
insulin signaling causes diabetes, leading to blood glucose instability and many associated …
insulin signaling causes diabetes, leading to blood glucose instability and many associated …
Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts
Permeability enhancer-based formulations offer a promising approach to enhance the oral
bioavailability of peptides. We used all-atom molecular dynamics simulations to investigate …
bioavailability of peptides. We used all-atom molecular dynamics simulations to investigate …
Recent advances in oral insulin delivery technologies
With the rise in diabetes mellitus cases worldwide, oral delivery of insulin is preferred over
subcutaneous insulin administration due to its good patient compliance and non …
subcutaneous insulin administration due to its good patient compliance and non …