N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye

P Deshpande, AV Chimata, E Snider, A Singh… - Cell Death & …, 2023 - nature.com
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests as
accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of …

Quantifying innervation facilitated by deep learning in wound healing

AS Mehta, S Teymoori, C Recendez, D Fregoso… - Scientific Reports, 2023 - nature.com
The peripheral nerves (PNs) innervate the dermis and epidermis, and are suggested to play
an important role in wound healing. Several methods to quantify skin innervation during …

[HTML][HTML] Protocol to study cell death using TUNEL assay in Drosophila imaginal discs

AV Chimata, P Deshpande, AS Mehta, A Singh - STAR protocols, 2022 - Elsevier
Cell death maintains tissue homeostasis by eliminating dispensable cells. Misregulation of
cell death is seen in diseases like cancer, neurodegeneration, etc. Therefore, cell death …

Decellularized biohybrid nerve promotes motor axon projections

AS Mehta, SL Zhang, X Xie, S Khanna… - Advanced …, 2024 - Wiley Online Library
Developing nerve grafts with intact mesostructures, superior conductivity, minimal
immunogenicity, and improved tissue integration is essential for the treatment and …

Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis in Drosophila eye

AV Chimata, H Darnell, A Raj, M Kango-Singh… - Autophagy …, 2023 - Taylor & Francis
During organogenesis cellular homeostasis plays a crucial role in patterning and growth.
The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of …

Highly regenerative species-specific genes improve age-associated features in the adult Drosophila midgut

H Nagai, Y Adachi, T Nakasugi, E Takigawa, J Ui… - BMC biology, 2024 - Springer
Background The remarkable regenerative abilities observed in planarians and cnidarians
are closely linked to the active proliferation of adult stem cells and the precise differentiation …

A Drosophila model of HPV16-induced cancer reveals conserved disease mechanism

L Hashemi, MKE Ormsbee, PJ Patel, JA Nielson… - PloS one, 2022 - journals.plos.org
High-risk human papillomaviruses (HR-HPVs) cause almost all cervical cancers and a
significant number of vaginal, vulvar, penile, anal, and oropharyngeal cancers. HPV16 and …

[图书][B] Computational Strategies for Optimizing Wound Healing: From Neurite Analysis to Deep Reinforcement Learning

S Teymoori - 2023 - search.proquest.com
The primary objective of this thesis is to expedite the intricate process of wound healing
through a multifaceted computational approach. Our journey commences by delving into the …