Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is
frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

Abstract Dr. Thomas Dougherty and his Oncology Foundation of Buffalo were the first to
support my (SOG) research into the effects of photodynamic therapy (PDT) on the host …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

Highlights•PGE2 receptor subtypes EP1–4 are valuable drug targets.•Structural features for
subtype-selective activity of EP1–4 receptor modulators are presented.•Binding affinities …

Elevated expression of COX‐2 and increased levels of PGE2 are found in numerous
cancers and are associated with tumour development and progression. Although …

TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor
suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 …