tRNA renovatio: rebirth through fragmentation

B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Emerging functional principles of tRNA-derived small RNAs and other regulatory small RNAs

Q Chen, T Zhou - Journal of Biological Chemistry, 2023 - ASBMB
Recent advancements in small RNA sequencing have unveiled a previously hidden world of
regulatory small noncoding RNAs (sncRNAs) that extend beyond the well-studied small …

[HTML][HTML] The Function and Therapeutic Potential of Transfer RNA-Derived Small RNAs in Cardiovascular Diseases: A Review

K Wang, CY Liu, B Fang, B Li, YH Li, QQ Xia… - Pharmacological …, 2024 - Elsevier
Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNA (sncRNA)
molecules derived from tRNA, including tRNA derived fragments (tRFs) and tRNA halfs …

Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring

R Hernandez, X Li, J Shi, TR Dave, T Zhou… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Emerging studies suggest that various parental exposures affect offspring cardiovascular
health, yet the specific mechanisms, particularly the influence of paternal cardiovascular …

Novel insights into transfer RNA-derived small RNA (tsRNA) in cardio-metabolic diseases

Q Zhang, X Zhao, M Sun, D Dong - Life Sciences, 2024 - Elsevier
Cardio-metabolic diseases, including a cluster of metabolic disorders and their secondary
affections on cardiovascular physiology, are gradually brought to the forefront by …

Exploring the Regulatory Role of tsRNAs in the TNF Signaling Pathway: Implications for Cancer and Non-Cancer Diseases

Q Wang, Q Huang, X Ying, Y Zhou, S Duan - Progress in Biophysics and …, 2024 - Elsevier
Transfer RNA-derived small RNAs (tsRNAs), a recently identified subclass of small non-
coding RNAs (sncRNAs), emerge through the cleavage of mature transfer RNA (tRNA) or …

[HTML][HTML] Insight into noncanonical small noncoding RNAs in Influenza A virus infection

EA Ko, T Zhou, JH Ko - Virus Research, 2024 - Elsevier
Influenza A virus (IAV) induces acute respiratory infections in birds and various mammals,
including humans, and presents a significant global public health concern, with …

Small non‐coding RNA signatures in atrial appendages of patients with atrial fibrillation

Y Zeng, Z Yuan, J Li, L Yang, C Li… - Journal of Cellular …, 2024 - Wiley Online Library
The development of high‐throughput technologies has enhanced our understanding of
small non‐coding RNAs (sncRNAs) and their crucial roles in various diseases, including …

Optimizing of a suitable protocol for isolating tissue‐derived extracellular vesicles and profiling small RNA patterns in hepatocellular carcinoma

W Yang, Y Liu, J Wang, T Liu, T Tian, T Li… - Liver …, 2024 - Wiley Online Library
Abstract Background Extracellular vesicles (EVs) facilitate cell–cell interactions in the tumour
microenvironment. However, standard and efficient methods to isolate tumour tissue …

Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis

EM Semler, DL Michell, PJ Kingsley, C Massick… - bioRxiv, 2024 - biorxiv.org
Epitranscriptomic modifications on RNA play critical roles in stability, processing, and
function, partly by influencing interactions with RNA-binding proteins and receptors. The role …