Interactions between microbiota and cervical epithelial, immune, and mucus barrier

M Dong, Y Dong, J Bai, H Li, X Ma, B Li… - Frontiers in cellular …, 2023 - frontiersin.org
The female reproductive tract harbours hundreds of bacterial species and produces
numerous metabolites. The uterine cervix is located between the upper and lower parts of …

Relationship between human papillomavirus status and the cervicovaginal microbiome in cervical cancer

HDT Nguyen, TM Le, E Lee, D Lee, Y Choi, J Cho… - Microorganisms, 2023 - mdpi.com
Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent
infection with high-risk human papillomavirus (HR-HPV). However, it is widely …

Lactic acid enhances vaginal epithelial barrier integrity and ameliorates inflammatory effects of dysbiotic short chain fatty acids and HIV-1

I Schwecht, A Nazli, B Gill, C Kaushic - Scientific Reports, 2023 - nature.com
The vaginal microenvironment is key in mediating susceptibility to sexually transmitted
infections. A polymicrobial environment with reduced Lactobacilllus spp. is characteristic of …

Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota

X Shen, L Xu, Z Zhang, Y Yang, P Li, T Ma… - Frontiers in Cellular …, 2023 - frontiersin.org
Vaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of
bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of …

A bibliometric analysis of the global impact of metaproteomics research

AA Ascandari, S Aminu, NEH Safdi, A El Allali… - Frontiers in …, 2023 - frontiersin.org
Background Metaproteomics is a subfield in meta-omics that is used to characterize the
proteome of a microbial community. Despite its importance and the plethora of publications …

Clinical relevance of vaginal and endometrial microbiome investigation in women with repeated implantation failure and recurrent pregnancy loss

X Gao, YV Louwers, JSE Laven… - International Journal of …, 2024 - mdpi.com
Recent studies have investigated if and how the vaginal and endometrial microbiome might
affect endometrial receptivity and reproductive health. Although there is no consensus on …

The human vaginal microbiota: from clinical medicine to models to mechanisms

S Ottinger, CM Robertson, H Branthoover… - Current Opinion in …, 2024 - Elsevier
Highlights●Live microbial biotherapeutics are emerging treatments for bacterial
vaginosis.●Metagenomics reveal vaginal subspecies are differentially associated with …

Advances in mass spectrometry technologies to characterize cervicovaginal microbiome functions that impact spontaneous preterm birth

L Masson, J Wilson, AS Amir Hamzah… - American Journal of …, 2023 - Wiley Online Library
Preterm birth (PTB) is a leading cause of morbidity and mortality in young children. Infection
is a major cause of this adverse outcome, particularly in PTBs characterised by spontaneous …

Non-Lactobacillus-Dominant and Polymicrobial Vaginal Microbiomes Are More Common in Younger South African Women and Predictive of Increased Risk of …

Y Wang, L Noël-Romas, M Perner… - Clinical Infectious …, 2023 - academic.oup.com
Background Adolescent girls and young women aged 15‒24 years in sub-Saharan Africa
are at disproportionate risk of human immunodeficiency virus (HIV) infection. Given the …

MetaNovo: An open-source pipeline for probabilistic peptide discovery in complex metaproteomic datasets

MG Potgieter, AJM Nel, S Fortuin… - PLOS Computational …, 2023 - journals.plos.org
Background Microbiome research is providing important new insights into the metabolic
interactions of complex microbial ecosystems involved in fields as diverse as the …