Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism

J Gao, K Xu, H Liu, G Liu, M Bai, C Peng… - Frontiers in cellular and …, 2018 - frontiersin.org
The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

Neurotransmitters: The critical modulators regulating gut–brain axis

R Mittal, LH Debs, AP Patel, D Nguyen… - Journal of cellular …, 2017 - Wiley Online Library
Neurotransmitters, including catecholamines and serotonin, play a crucial role in
maintaining homeostasis in the human body. Studies on these neurotransmitters mainly …

A tissue-like neurotransmitter sensor for the brain and gut

J Li, Y Liu, L Yuan, B Zhang, ES Bishop, K Wang… - Nature, 2022 - nature.com
Neurotransmitters play essential roles in regulating neural circuit dynamics both in the
central nervous system as well as at the peripheral, including the gastrointestinal tract …

The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine

N Liu, S Sun, P Wang, Y Sun, Q Hu… - International journal of …, 2021 - mdpi.com
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

GM Mawe, JM Hoffman - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

BB Williams, AH Van Benschoten, P Cimermancic… - Cell host & …, 2014 - cell.com
Several recent studies describe the influence of the gut microbiota on host brain and
behavior. However, the mechanisms responsible for microbiota-nervous system interactions …

Tryptophan metabolites along the microbiota-gut-brain axis: an interkingdom communication system influencing the gut in health and disease

A Bosi, D Banfi, M Bistoletti… - International Journal of …, 2020 - journals.sagepub.com
The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …

The diverse metabolic roles of peripheral serotonin

AM Martin, RL Young, L Leong, GB Rogers… - …, 2017 - academic.oup.com
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

MD Gershon, J Tack - Gastroenterology, 2007 - Elsevier
Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger
utilized by enterochromaffin (EC) cells, which function as sensory transducers. Serotonin …

[HTML][HTML] Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis

YH Kwon, H Wang, E Denou, JE Ghia, L Rossi… - Cellular and molecular …, 2019 - Elsevier
Background & Aims Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within
enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate …