Lipid droplets in chordates are decorated by two or more members of the perilipin family of
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …

Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …

Background Familial chylomicronemia syndrome is a rare genetic disorder that is caused by
loss of lipoprotein lipase activity and characterized by chylomicronemia and recurrent …

Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the
hydrolysis of triglycerides, declines with age,. The defect in the mobilization of free fatty acids …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Stem cells reside in specialized microenvironments known as niches. During Drosophila
development, glial cells provide a niche that sustains the proliferation of neural stem cells …

Lipid droplets are intracellular organelles that are found in most cells, where they have
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …