This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Cyclotides are a novel class of micro-proteins (≈ 30–40 residues long) with a unique
topology containing a head-to-tail cyclized backbone structure further stabilized by three …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

Cyclotides represent a new class of natural plant compounds, which could be considered
ideal “template” molecules for drug design. Their structure is characterized by a circular …

Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot
topology that confers them with remarkable structural stability and resistance to proteolytic …

Cyclotides are mini-proteins with potent bioactivities and outstanding potential for
agricultural and pharmaceutical applications. More than 450 different plant cyclotides have …

Cyclotides are plant-derived disulfide-rich peptides comprising a cyclic cystine knot, which
confers remarkable stability against thermal, proteolytic, and chemical degradation. They …

Abstract The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR)
that is expressed in peripheral tissues and the central nervous system and constitutes a …

Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous
system that causes chronic inflammation. Cyclotides are small plant proteins with a wide …

Melatonin is a tryptophan derivative synthesized in plants and animals. In humans,
melatonin acts on melatonin MT 1 and MT 2 receptors belonging to the G protein-coupled …