Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

Type I and type III interferons (IFNs) share several properties in common, including the
induction of signaling pathways, the activation of gene transcripts, and immune responses …

Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating
inflammatory responses among various allergic disorders (such as atopic dermatitis, food …

Systemic lupus erythematosus (SLE) is an idiopathic chronic autoimmune disease that can
affect any organ in the body, including the neurological system. Multiple factors, such as …

Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint
damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is …

Objectives The difficulty of monitoring organ-specific pathology in systemic lupus
erythematosus (SLE) often complicates disease prognostication and treatment. Improved …

Abstract Haploinsufficiency of A20 (HA20) is a newly described immune dysregulation
disease due to the loss-of-function mutation in TNFAIP3. In the present study, we report six …

Background Accumulating evidence has demonstrated the associations of omega-3 or
omega-6 polyunsaturated fatty acids (PUFAs) with the disease activity and inflammatory …

Motivation A critical element of drug development is the identification of therapeutic targets
for diseases. However, the depletion of therapeutic targets is a serious problem. Results In …

As in many autoimmune diseases, the pathogenesis of the antiphospholipid syndrome
(APS) is the result of a complex interplay between predisposing genes and triggering …